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The upstream build instructions at https://github.com/keepassx/keepassx use Qt5 to build the package. I just built the binaries myself using Qt5 on Fedora 24, which worked fine. Fedora should ship KeepassX with Qt5 as well, which provides better desktop theme integration and wayland compatibility.
KeePassX 2.1 will support Qt5 only. KeePassX 2.0 is still Qt4 https://www.keepassx.org/news/2015/12/533/comment-page-1#comment-253555 https://forum.keepassx.org/viewtopic.php?t=3884