Description of problem:
This happens whenever systemd generators are run, i.e. during boot or when running "systemctl daemon-reload".
I do not have /boot listed in /etc/fstab and rely on systemd-gpt-auto-generator to find the EFI System Partition and generate the mount and automount units for it.

To allow this access (and related ones), audit2allow generated the following module:

module my-systemdgptaut 1.0;

require {
        type efivarfs_t;
        type systemd_gpt_generator_t;
        class file { getattr open read };
}

#============= systemd_gpt_generator_t ==============
allow systemd_gpt_generator_t efivarfs_t:file { getattr open read };
SELinux is preventing systemd-gpt-aut from 'open' accesses on the file /sys/firmware/efi/efivars/LoaderDevicePartUUID-4a67b082-0a4c-41cf-b6c7-440b29bb8c4f.

*****  Plugin restorecon (99.5 confidence) suggests   ************************

If you want to fix the label. 
/sys/firmware/efi/efivars/LoaderDevicePartUUID-4a67b082-0a4c-41cf-b6c7-440b29bb8c4f default label should be sysfs_t.
Then you can run restorecon.
Do
# /sbin/restorecon -v /sys/firmware/efi/efivars/LoaderDevicePartUUID-4a67b082-0a4c-41cf-b6c7-440b29bb8c4f

*****  Plugin catchall (1.49 confidence) suggests   **************************

If you believe that systemd-gpt-aut should be allowed open access on the LoaderDevicePartUUID-4a67b082-0a4c-41cf-b6c7-440b29bb8c4f file by default.
Then you should report this as a bug.
You can generate a local policy module to allow this access.
Do
allow this access for now by executing:
# ausearch -c 'systemd-gpt-aut' --raw | audit2allow -M my-systemdgptaut
# semodule -X 300 -i my-systemdgptaut.pp

Additional Information:
Source Context                system_u:system_r:systemd_gpt_generator_t:s0
Target Context                system_u:object_r:efivarfs_t:s0
Target Objects                /sys/firmware/efi/efivars/LoaderDevicePartUUID-4a6
                              7b082-0a4c-41cf-b6c7-440b29bb8c4f [ file ]
Source                        systemd-gpt-aut
Source Path                   systemd-gpt-aut
Port                          <Unknown>
Host                          (removed)
Source RPM Packages           
Target RPM Packages           
Policy RPM                    selinux-policy-3.13.1-225.3.fc25.noarch
Selinux Enabled               True
Policy Type                   targeted
Enforcing Mode                Permissive
Host Name                     (removed)
Platform                      Linux (removed) 4.8.13-300.fc25.x86_64 #1 SMP Fri
                              Dec 9 14:52:00 UTC 2016 x86_64 x86_64
Alert Count                   1
First Seen                    2016-12-12 16:31:19 CET
Last Seen                     2016-12-12 16:31:19 CET
Local ID                      673c88b1-14b9-4f7e-ab92-1fd1acb09806

Raw Audit Messages
type=AVC msg=audit(1481556679.91:208): avc:  denied  { open } for  pid=4713 comm="systemd-gpt-aut" path="/sys/firmware/efi/efivars/LoaderDevicePartUUID-4a67b082-0a4c-41cf-b6c7-440b29bb8c4f" dev="efivarfs" ino=12309 scontext=system_u:system_r:systemd_gpt_generator_t:s0 tcontext=system_u:object_r:efivarfs_t:s0 tclass=file permissive=1


Hash: systemd-gpt-aut,systemd_gpt_generator_t,efivarfs_t,file,open

Version-Release number of selected component:
selinux-policy-3.13.1-225.3.fc25.noarch

Additional info:
reporter:       libreport-2.8.0
hashmarkername: setroubleshoot
kernel:         4.8.13-300.fc25.x86_64
type:           libreport