The computer is extremly slow when the locate process run (anacron wake it
up). Please add this line to the file /etc/cron.daily/slocate.cron

renice +19 -p $$ > /dev/null 2>&1

renice claim new value and this output should go to /dev/null

Without this the machine is almost unusable, especially when there are
large disks or slow processor in the computer.