The new autoconf has some useful macros (esp AC_SYS_LARGEFILE). It would be great if the next version of the Redhat was to include it. The lastest from ftp.gnu org seems to be autoconf-2.52.
AFAIK Florian is working on this ATM.
autoconf-2.52 is in rawhide. *** This bug has been marked as a duplicate of 53027 ***