Can you provide the XML configuration, and the full debug logs for libvirtd starting from the time the guest was booted.

xml configuration: 

[root@silver-vdse tmp]# virsh dumpxml 142
<domain type='kvm' id='142'>
  <name>libvirt-rhel54-033</name>
  <uuid>71f0923d-20b9-4652-b873-6e8331fe14e9</uuid>
  <memory>524288</memory>
  <currentMemory>524288</currentMemory>
  <vcpu>1</vcpu>
  <os>
    <type arch='x86_64' machine='rhel6.0.0'>hvm</type>
    <boot dev='hd'/>
  </os>
  <features>
    <acpi/>
  </features>
  <cpu match='exact'>
    <model>qemu64</model>
    <topology sockets='1' cores='1' threads='1'/>
    <feature policy='require' name='sse2'/>
    <feature policy='disable' name='svm'/>
  </cpu>
  <clock offset='variable' adjustment='-25200'/>
  <on_poweroff>destroy</on_poweroff>
  <on_reboot>restart</on_reboot>
  <on_crash>destroy</on_crash>
  <devices>
    <emulator>/usr/libexec/qemu-kvm</emulator>
    <disk type='block' device='disk'>
      <driver name='qemu' type='qcow2' cache='none'/>
      <source dev='/rhev/data-center/841af73a-d3bf-4bb8-9985-0603fdcf302e/aaac4a9b-ae1f-4e4b-9c71-d25eb10bc83f/images/85dda418-8b5a-462c-b66d-0f86f887f704/1ff0a695-8489-4908-87c0-9d30c7f74feb'/>
      <target dev='hda' bus='virtio'/>
      <serial>2c-b66d-0f86f887f704</serial>
      <alias name='virtio-disk0'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x04' function='0x0'/>
    </disk>
    <disk type='block' device='disk'>
      <driver name='qemu' type='qcow2' cache='none'/>
      <source dev='/rhev/data-center/841af73a-d3bf-4bb8-9985-0603fdcf302e/aaac4a9b-ae1f-4e4b-9c71-d25eb10bc83f/images/95e2c849-eea2-488e-b5c5-db32ddb5a9d7/1e04df65-ab99-4bc5-b0be-93085dede825'/>
      <target dev='hdb' bus='virtio'/>
      <serial>8e-b5c5-db32ddb5a9d7</serial>
      <alias name='virtio-disk1'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x05' function='0x0'/>
    </disk>
    <controller type='virtio-serial' index='0' ports='16'>
      <alias name='virtio-serial0'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x07' function='0x0'/>
    </controller>
    <interface type='bridge'>
      <mac address='00:1a:4a:23:71:4f'/>
      <source bridge='rhevm'/>
      <target dev='vnet37'/>
      <model type='virtio'/>
      <alias name='net0'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x06' function='0x0'/>
    </interface>
    <channel type='unix'>
      <source mode='bind' path='/var/lib/libvirt/qemu/channels/libvirt-rhel54-033.org.linux-kvm.port.0'/>
      <target type='virtio' name='org.linux-kvm.port.0'/>
      <alias name='channel0'/>
      <address type='virtio-serial' controller='0' bus='0' port='0'/>
    </channel>
    <input type='tablet' bus='usb'>
      <alias name='input0'/>
    </input>
    <input type='mouse' bus='ps2'/>
    <graphics type='vnc' port='5937' autoport='yes' listen='0' keymap='en-us'/>
    <video>
      <model type='cirrus' vram='9216' heads='1'/>
      <alias name='video0'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x02' function='0x0'/>
    </video>
  </devices>
  <seclabel type='dynamic' model='selinux'>
    <label>system_u:system_r:svirt_t:s0:c718,c777</label>
    <imagelabel>system_u:object_r:svirt_image_t:s0:c718,c777</imagelabel>
  </seclabel>
</domain>


LC_ALL=C PATH=/sbin:/usr/sbin:/bin:/usr/bin QEMU_AUDIO_DRV=none /usr/libexec/qemu-kvm -S -M rhel6.0.0 -cpu qemu64,-svm -enable-kvm -m 512 -smp 1,sockets=1,cores=1,threads=1 -name libvirt-rhel54-033 -uuid 71f0923d-20b9-4652-b873-6e8331fe14e9 -nodefconfig -nodefaults -chardev socket,id=monitor,path=/var/lib/libvirt/qemu/libvirt-rhel54-033.monitor,server,nowait -mon chardev=monitor,mode=control -rtc base=2010-6-14T5:12:49 -boot c -device virtio-serial-pci,id=virtio-serial0,max_ports=16,bus=pci.0,addr=0x7 -drive file=/rhev/data-center/841af73a-d3bf-4bb8-9985-0603fdcf302e/aaac4a9b-ae1f-4e4b-9c71-d25eb10bc83f/images/85dda418-8b5a-462c-b66d-0f86f887f704/1ff0a695-8489-4908-87c0-9d30c7f74feb,if=none,id=drive-virtio-disk0,boot=on,format=qcow2,serial=2c-b66d-0f86f887f704,cache=none -device virtio-blk-pci,bus=pci.0,addr=0x4,drive=drive-virtio-disk0,id=virtio-disk0 -drive file=/rhev/data-center/841af73a-d3bf-4bb8-9985-0603fdcf302e/aaac4a9b-ae1f-4e4b-9c71-d25eb10bc83f/images/95e2c849-eea2-488e-b5c5-db32ddb5a9d7/1e04df65-ab99-4bc5-b0be-93085dede825,if=none,id=drive-virtio-disk1,format=qcow2,serial=8e-b5c5-db32ddb5a9d7,cache=none -device virtio-blk-pci,bus=pci.0,addr=0x5,drive=drive-virtio-disk1,id=virtio-disk1 -netdev tap,fd=60,id=hostnet0,vhost=on,vhostfd=61 -device virtio-net-pci,netdev=hostnet0,id=net0,mac=00:1a:4a:23:71:4f,bus=pci.0,addr=0x6 -chardev socket,id=channel0,path=/var/lib/libvirt/qemu/channels/libvirt-rhel54-033.org.linux-kvm.port.0,server,nowait -device virtserialport,bus=virtio-serial0.0,nr=0,chardev=channel0,name=org.linux-kvm.port.0 -usb -device usb-tablet,id=input0 -vnc 0:37,password -k en-us -vga cirrus -incoming exec:cat -device virtio-balloon-pci,id=balloon0,bus=pci.0,addr=0x3 
cat: write error: Broken pipe
kvm: unhandled exit 31
kvm_run returned -22
kvm: unhandled exit 31
kvm_run returned -22
kvm: unhandled exit 31
kvm_run returned -22
kvm: unhandled exit 31
kvm_run returned -22
kvm: unhandled exit 31
kvm_run returned -22


is it enough ?

This last KVM error message

  kvm_run returned -22

Comes from this code:

  int kvm_cpu_exec(CPUState *env)
  {
    int r;

    r = kvm_run(env);
    if (r < 0) {
        printf("kvm_run returned %d\n", r);
        vm_stop(0);
    }

    return 0;
  }


which explains why libvirt is getting a 'PAUSE' event notification for the guest that is not related to an I/O error.

This previous error message

  kvm: unhandled exit 31

indicates some kind of flaw in KVM.

Can you set ksm off and re-try? We had a similar exit message due to ksm bug.

This issue has been proposed when we are only considering blocker
issues in the current Red Hat Enterprise Linux release. It has
been denied for the current Red Hat Enterprise Linux release.

** If you would still like this issue considered for the current
release, ask your support representative to file as a blocker on
your behalf. Otherwise ask that it be considered for the next
Red Hat Enterprise Linux release. **

Dor - removed KSM from cluster (using rhevm) and I still cannot resume the vm. 
get the following error in libvirtd.log. 

15:06:23.245: debug : qemuHandleDomainStop:1307 : Transitioned guest libvirt-rhel54-44 to paused state due to unknown event

Are you using the latest kernel (.44) and qemu-kvm (qemu-kvm-0.12.1.2-2.96.el6)

2.6.32-44.el6.x86_64
qemu-kvm-0.12.1.2-2.96.el6.x86_64

I would suggest checking it doesn't happen with this build (especially if host hits swapping):

https://brewweb.devel.redhat.com/taskinfo?taskID=2603333


no need to disable KSM or THP with this build.

QE, please test the above

Isn't this #606131?

Yes, it's bug #606131 I asked to test the build to be sure.. but we can probably safely mark it as dup already.

*** This bug has been marked as a duplicate of bug 606131 ***