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yum-builddep should have a --target option so I can run it on an x86_64 host with --target=i686 to install the needed *-devel.i686 rpms.
This has been implemented upstream for some time now (see bug 734983). yum-builddep in Fedora >= 17 has the needed bits but it requires rpm support as well, and that's only currently available in rpm >= 4.9.90 which landed in rawhide today.