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When you save a topic, skynet should verify that all the injection points have valid relationships. If not it should present you with the list of the topics that will have to have relationships created, and allow you to specify if it should be one-way or two-way for each one. Then click done to save the relationships.
Relationships will be defined in a CSP map in future. Because it is not possible to know what topics are going to be present in a map, it won't be possible to prevent a topic from being saved with incorrect injections. I think long term the injection points will be removed anyway.