Istio through 1.5.1 and Envoy through 1.14.1 have a data-leak issue. If there is a TCP connection (negotiated with SNI over HTTPS) to *.example.com, a request for a domain concurrently configured explicitly (e.g., abc.example.com) is sent to the server(s) listening behind *.example.com. The outcome should instead be 421 Misdirected Request. Imagine a shared caching forward proxy re-using an HTTP/2 connection for a large subnet with many users. If a victim is interacting with abc.example.com, and a server (for abc.example.com) recycles the TCP connection to the forward proxy, the victim's browser may suddenly start sending sensitive data to a *.example.com server. This occurs because the forward proxy between the victim and the origin server reuses connections (which obeys the specification), but neither Istio nor Envoy corrects this by sending a 421 error. Similarly, this behavior voids the security model browsers have put in place between domains.

References:
https://bugs.chromium.org/p/chromium/issues/detail?id=954160#c5
https://github.com/envoyproxy/envoy/issues/6767
https://github.com/istio/istio/issues/13589
https://github.com/istio/istio/issues/9429