When a seuser user_u starts wine, the application is run with the context user_wine_t, but this context does not handle wine_home_t, which is the label of the wine home directory. Using the tool sesearch, we can see that the rules are defined for wine_t.

I have used the command in permissive mode to get all the denials. Here a summary:

First problem: when wine is started for the first time, it creates its home directory .wine, but with the wrong label user_home_dir_t. Restorecon fixes this label and set it to wine_home_t.

Second problem: wine cannot access its configuration directory. Audit2allow reports:

allow user_wine_t data_home_t:file { write create unlink };
allow user_wine_t wine_home_t:dir { write remove_name add_name };
allow user_wine_t wine_home_t:file { write rename create unlink setattr };
allow user_wine_t wine_home_t:lnk_file read;

The data_home_t is for the .desktop files and icons in .local/share.

The same problems exist for seuser staff_u.