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Description of problem:
Orca accessibility screen reader doesn't read anything in Firefox (and Thunderbird as well), thus it makes it impossible for visually impaired to use it.  

I also tested it on Fedora 22 where the new GTK3-based Firefox doesn't work with Orca reader either.

Is that a dupe of https://bugzilla.redhat.com/show_bug.cgi?id=1067395 ? i.e. FF has to be restarted when accessibility is enabled.

Seems so, when I restart Firefox, it indeed starts working with the reader.

*** This bug has been marked as a duplicate of bug 1067395 ***

As the bug that this one is supposed to duplicate has been supposedly fixed since 3.22 and FF 52, but the symptom of Orca not having access to Firefox and Thunderbird w/o restart remains in FF 92 and Orca 40.0, I guess this bug should be reopened?

Firefox has this tracked as well https://bugzilla.mozilla.org/show_bug.cgi?id=1601840

Also, see this discussion within the Orca team: https://gitlab.gnome.org/GNOME/orca/-/issues/212