Description of problem:
When using optirun to call any program the result is as the following:
[  296.024207] [ERROR]Cannot access secondary GPU - error: [XORG] (EE) /dev/dri/card0: failed to set DRM interface version 1.4: Permission denied

[  296.024244] [ERROR]Aborting because fallback start is disabled.

When I stopped the services and runned bumblebeed -D it worked as expected.
$systemctl stop bumblebeed.service
$systemctl stop bumblebee-nvidia.service
$bumblebeed -D

optirun will now work as expected

Version-Release number of selected component (if applicable):
#bumblebeed --version
bumblebeed (Bumblebee) 3.2.1

$bumblebee-nvidia -c

nvidia.ko compiled into in the kernel tree ok.
modinfo output for NVIDIA:

filename:       /lib/modules/4.0.4-301.fc22.x86_64/kernel/drivers/video/nvidia.ko
alias:          char-major-195-*
version:        346.72
supported:      external
license:        NVIDIA
alias:          pci:v000010DEd00000E00sv*sd*bc04sc80i00*
alias:          pci:v000010DEd00000AA3sv*sd*bc0Bsc40i00*
alias:          pci:v000010DEd*sv*sd*bc03sc02i00*
alias:          pci:v000010DEd*sv*sd*bc03sc00i00*
depends:        drm
vermagic:       4.0.4-301.fc22.x86_64 SMP mod_unload 
parm:           NVreg_Mobile:int
parm:           NVreg_ResmanDebugLevel:int
parm:           NVreg_RmLogonRC:int
parm:           NVreg_ModifyDeviceFiles:int
parm:           NVreg_DeviceFileUID:int
parm:           NVreg_DeviceFileGID:int
parm:           NVreg_DeviceFileMode:int
parm:           NVreg_RemapLimit:int
parm:           NVreg_UpdateMemoryTypes:int
parm:           NVreg_InitializeSystemMemoryAllocations:int
parm:           NVreg_UsePageAttributeTable:int
parm:           NVreg_MapRegistersEarly:int
parm:           NVreg_RegisterForACPIEvents:int
parm:           NVreg_CheckPCIConfigSpace:int
parm:           NVreg_EnablePCIeGen3:int
parm:           NVreg_EnableMSI:int
parm:           NVreg_MemoryPoolSize:int
parm:           NVreg_RegistryDwords:charp
parm:           NVreg_RmMsg:charp
parm:           NVreg_AssignGpus:charp

Check bbswitch kernel module...

bbswitch is loaded into the current kernel ok.

All checks completed successfully! NVIDIA driver appears to have compiled ok.

Fedora 22
Linux renatomefi.dev 4.0.4-301.fc22.x86_64 #1 SMP Thu May 21 13:10:33 UTC 2015 x86_64 x86_64 x86_64 GNU/Linux