Multiple property substitution is working with EAP 6.4.3+, however, if a variable amongst the multiple variables is empty or has no value, then the subsequent property in the CLI command is not substituted. 

For example : 
cat props.properties 
-----------------------------------------
PROFILE-NAME=TestProfile
SERVER-INSTANCE-NUMBER=TestInstance
APP-VERSION=
VAR=test
-----------------------------------------

cat test.cli :
---------------------------------------
/host=master/server-config=${PROFILE-NAME}${APP-VERSION}${SERVER-INSTANCE-NUMBER}${VAR}:add(auto-start=true, group="${PROFILE-NAME}${APP-VERSION}-server-group")
---------------------------------------

and if I execute "./jboss-cli.sh --connect --file=test.cli --properties=props.properties" then I have the following in the host.xml ": 

----------
...
<server name="TestProfile${SERVER-INSTANCE-NUMBER}test" group="TestProfile-server-group" auto-start="true"/>
...
-----------

Note APP-VERSION had no value, and so the subsequent SERVER-INSTANCE-NUMBER was not properly resolved