On upgrading to python2-cryptography-1.5.3-1.fc26, fedpkg clone now gives me: 

% fedpkg clone certbot
Traceback (most recent call last):
  File "/usr/bin/fedpkg", line 13, in <module>
    from fedpkg.__main__ import main
  File "/usr/lib/python2.7/site-packages/fedpkg/__init__.py", line 12, in <module>
    import pyrpkg
  File "/usr/lib/python2.7/site-packages/pyrpkg/__init__.py", line 24, in <module>
    import koji
  File "/usr/lib/python2.7/site-packages/koji/__init__.py", line 51, in <module>
    import ssl.SSLCommon
  File "/usr/lib/python2.7/site-packages/koji/ssl/SSLCommon.py", line 18, in <module>
    from OpenSSL import SSL
  File "/usr/lib/python2.7/site-packages/OpenSSL/__init__.py", line 8, in <module>
    from OpenSSL import rand, crypto, SSL
  File "/usr/lib/python2.7/site-packages/OpenSSL/SSL.py", line 124, in <module>
    SSL_ST_INIT = _lib.SSL_ST_INIT
AttributeError: 'module' object has no attribute 'SSL_ST_INIT'

Downgrading to python2-cryptography-1.3.1-4.fc25 everything works again.