When trying to build pygame on ppc64le the %check section fails:

FAIL: make sure the color key is not changed when saving.
----------------------------------------------------------------------
Traceback (most recent call last):
  File "test/image_test.py", line 284, in test_save_colorkey
    self.assertEqual(p1, s2.get_at((0,0)))
AssertionError: (23, 23, 23, 255) != (23, 23, 255, 23)
----------------------------------------------------------------------

Although only the last 2 bytes of the 32 bit are swapped, which
is weird. To make sure this really is an endian-ness issue
I've also started a scratchbuild for just ppc64 and that
did complete successfully.

Looking at pygame itself, there seems to be no ppc specific
code in there, all endian specific bits are done based on
SDL_BYTEORDER which does get set correctly on ppc64le.

Looking at SDL there also is not a whole lot of ppc specific
code (I've grepped for both ppc and powerpc) and certainly
nothing which would explain this.