Per summary, the appliance configuration UI should indicate which of the roles are zone vs region aware. A further enhancement may be to have on each the Region and Zone summary page a quick status check to validate enough roles are enabled for full functionality.
Please assess the impact of this issue and update the severity accordingly. Please refer to https://bugzilla.redhat.com/page.cgi?id=fields.html#bug_severity for a reminder on each severity's definition. If it's something like a tracker bug where it doesn't matter, please set the severity to Low.
This is documented