/usr/lib64/guile/2.0/guile-gnutls-v-2.so.0.0.0 in gnutls-guile-3.6.2-1.fc28.x86_64 is not linked with the standard Fedora linker flags (LDFLAGS) from redhat-rpm-config. It seems the reason is an explicit -z lazy argument the linker. I doubt that this is necessary because the DSO is loaded from the Guile run-time, so all symbols (including those defined in the run-time) can be resolved at dlopen time, and lazy binding is not needed.
If it doesn't matter I wouldn't like to spend time on fixing it. It seems that the guile module is non functional if compiled with these flags (this change was implemented before and later reverted due to breakage). Can we add it into a whitelist?
We will not use hardening build flags for Guile extensions.