Your package rdkit failed to build from source in current F28. https://koji.fedoraproject.org/koji/taskinfo?taskID=24887607 For details on mass rebuild see https://fedoraproject.org/wiki/Fedora_28_Mass_Rebuild
It fails also if Fedora Rawhide and F27 with following error: [ 2%] Building CXX object Code/RDGeneral/CMakeFiles/RDGeneral.dir/LocaleSwitcher.cpp.o cd /builddir/build/BUILD/rdkit-Release_2016_09_4/python2/Code/RDGeneral && /usr/bin/c++ -DRDGeneral_EXPORTS -DRDK_64BIT_BUILD -DRDK_BUILD_DESCRIPTORS3D -DRDK_HAS_EIGEN3 -DRDK_TEST_MULTITHREADED -DRDK_USE_STRICT_ROTOR_DEFINITION -I/usr/include/inchi -I/usr/include/python2.7 -I/builddir/build/BUILD/rdkit-Release_2016_09_4/python2/Code -I/usr/include/eigen3 -O2 -g -pipe -Wall -Werror=format-security -Wp,-D_FORTIFY_SOURCE=2 -fexceptions -fstack-protector-strong --param=ssp-buffer-size=4 -grecord-gcc-switches -specs=/usr/lib/rpm/redhat/redhat-hardened-cc1 -m64 -mtune=generic -fasynchronous-unwind-tables -Wl,--as-needed -mpopcnt -Wno-deprecated -Wno-unused-function -fno-strict-aliasing -fPIC -Wall -Wextra -O2 -g -DNDEBUG -fPIC -DRDK_THREADSAFE_SSS -DBOOST_ALL_NO_LIB -o CMakeFiles/RDGeneral.dir/LocaleSwitcher.cpp.o -c /builddir/build/BUILD/rdkit-Release_2016_09_4/python2/Code/RDGeneral/LocaleSwitcher.cpp /builddir/build/BUILD/rdkit-Release_2016_09_4/python2/Code/RDGeneral/LocaleSwitcher.cpp:36:10: fatal error: xlocale.h: No such file or directory #include <xlocale.h> ^~~~~~~~~~~ compilation terminated. make[2]: *** [Code/RDGeneral/CMakeFiles/RDGeneral.dir/build.make:186: Code/RDGeneral/CMakeFiles/RDGeneral.dir/LocaleSwitcher.cpp.o] Error 1 make[2]: *** Waiting for unfinished jobs.... Additional info could be find here: https://apps.fedoraproject.org/koschei/package/rdkit
From glibc.spec: * Wed Jun 21 2017 Florian Weimer <fweimer> - 2.25.90-8 - Adjust build requirements for gcc, binutils, kernel-headers. - Auto-sync with upstream master, commit 43e0ac24c836eed627a75ca932eb7e64698407c6, changing: - Remove <xlocale.h>