Installed latest 4.3.0 pre release, hosted engine on 2 nodes with NFS storage.
Hosted engine is up and running but trying to create a new VM and launching it fails with VDSM log showing:

2019-01-24 11:52:36,803+0100 ERROR (vm/efe51494) [virt.vm] (vmId='efe51494-6f18-4864-b9d4-3e120b43d566') The vm start process failed (vm:937)
Traceback (most recent call last):
  File "/usr/lib/python2.7/site-packages/vdsm/virt/vm.py", line 866, in _startUnderlyingVm
    self._run()
  File "/usr/lib/python2.7/site-packages/vdsm/virt/vm.py", line 2845, in _run
    dom.createWithFlags(flags)
  File "/usr/lib/python2.7/site-packages/vdsm/common/libvirtconnection.py", line 131, in wrapper
    ret = f(*args, **kwargs)
  File "/usr/lib/python2.7/site-packages/vdsm/common/function.py", line 94, in wrapper
    return func(inst, *args, **kwargs)
  File "/usr/lib64/python2.7/site-packages/libvirt.py", line 1110, in createWithFlags
    if ret == -1: raise libvirtError ('virDomainCreateWithFlags() failed', dom=self)
libvirtError: internal error: qemu unexpectedly closed the monitor: 2019-01-24T10:52:36.491043Z qemu-kvm: warning: All CPU(s) up to maxcpus should be described in NUMA config, ability to start up with partial NU
MA mappings is obsoleted and will be removed in future

VM XML is;
2019-01-24 11:52:35,960+0100 INFO  (vm/efe51494) [virt.vm] (vmId='efe51494-6f18-4864-b9d4-3e120b43d566') <?xml version="1.0" encoding="utf-8"?><domain type="kvm" xmlns:ns0="http://ovirt.org/vm/tune/1.0" xmlns:ov
irt-vm="http://ovirt.org/vm/1.0">
    <name>ReactOS</name>
    <uuid>efe51494-6f18-4864-b9d4-3e120b43d566</uuid>
    <memory>524288</memory>
    <currentMemory>524288</currentMemory>
    <maxMemory slots="16">2097152</maxMemory>
    <vcpu current="1">16</vcpu>
    <sysinfo type="smbios">
        <system>
            <entry name="manufacturer">oVirt</entry>
            <entry name="product">oVirt Node</entry>
            <entry name="version">7-6.1810.2.el7.centos</entry>
            <entry name="serial">4c4c4544-0059-4310-8035-c4c04f595831</entry>
            <entry name="uuid">efe51494-6f18-4864-b9d4-3e120b43d566</entry>
        </system>
    </sysinfo>
    <clock adjustment="0" offset="variable">
        <timer name="hypervclock" present="yes"/>
        <timer name="rtc" tickpolicy="catchup"/>
        <timer name="pit" tickpolicy="delay"/>
        <timer name="hpet" present="no"/>
    </clock>
    <features>
        <acpi/>
        <hyperv>
            <relaxed state="on"/>
            <vapic state="on"/>
            <spinlocks retries="8191" state="on"/>
            <synic state="on"/>
            <stimer state="on"/>
        </hyperv>
    </features>
    <cpu match="exact">
        <model>SandyBridge</model>
        <feature name="pcid" policy="require"/>
        <feature name="spec-ctrl" policy="require"/>
        <feature name="ssbd" policy="require"/>
        <topology cores="1" sockets="16" threads="1"/>
        <numa>
            <cell cpus="0" id="0" memory="524288"/>
        </numa>
    </cpu>
    <cputune/>
    <devices>
        <input bus="ps2" type="mouse"/>
        <channel type="unix">
            <target name="ovirt-guest-agent.0" type="virtio"/>
            <source mode="bind" path="/var/lib/libvirt/qemu/channels/efe51494-6f18-4864-b9d4-3e120b43d566.ovirt-guest-agent.0"/>
        </channel>
        <channel type="unix">
            <target name="org.qemu.guest_agent.0" type="virtio"/>
            <source mode="bind" path="/var/lib/libvirt/qemu/channels/efe51494-6f18-4864-b9d4-3e120b43d566.org.qemu.guest_agent.0"/>
        </channel>

        <controller index="0" model="piix3-uhci" type="usb"/>
        <video>
            <model heads="1" ram="65536" type="qxl" vgamem="16384" vram="8192"/>
            <alias name="ua-d567d27d-0faf-406f-b7f4-4495f27b4659"/>
        </video>
        <rng model="virtio">
            <backend model="random">/dev/urandom</backend>
            <alias name="ua-f1da1bc8-6e2a-4c04-aa49-62a0d04d9a05"/>
        </rng>
        <graphics autoport="yes" passwd="*****" passwdValidTo="1970-01-01T00:00:01" port="-1" tlsPort="-1" type="spice">
            <channel mode="secure" name="main"/>
            <channel mode="secure" name="inputs"/>
            <channel mode="secure" name="cursor"/>
            <channel mode="secure" name="playback"/>
            <channel mode="secure" name="record"/>
            <channel mode="secure" name="display"/>
            <channel mode="secure" name="smartcard"/>
            <channel mode="secure" name="usbredir"/>
            <listen network="vdsm-ovirtmgmt" type="network"/>
        </graphics>
        <memballoon model="none"/>
        <channel type="spicevmc">
            <target name="com.redhat.spice.0" type="virtio"/>
        </channel>
        <disk device="cdrom" snapshot="no" type="file">
            <driver error_policy="report" name="qemu" type="raw"/>
            <source file="/rhev/data-center/043eb642-1fb0-11e9-a500-00163e3e843d/3f3ab345-0539-44df-9bc5-402435ed819f/images/163f110e-dd65-46e5-a84d-ef8687fc4a0e/52891de2-4282-4df9-a414-80350166d1ad" startupPoli
cy="optional">
                <seclabel model="dac" relabel="no" type="none"/>
            </source>
            <target bus="ide" dev="hdc"/>
            <readonly/>
            <alias name="ua-99878028-dd1a-4324-8b7e-3d51560ede51"/>
            <boot order="1"/>
        </disk>
        <disk device="disk" snapshot="no" type="file">
            <target bus="virtio" dev="vda"/>
            <source file="/rhev/data-center/mnt/minidell.home:_home_data/3f3ab345-0539-44df-9bc5-402435ed819f/images/9570d1a5-9587-4425-940a-6d9afa6136ea/a53ec4a6-b8ce-42a1-96d3-cdad72090d13">
                <seclabel model="dac" relabel="no" type="none"/>
            </source>
            <driver cache="none" error_policy="stop" io="threads" name="qemu" type="raw"/>
            <alias name="ua-9570d1a5-9587-4425-940a-6d9afa6136ea"/>
            <boot order="2"/>
            <serial>9570d1a5-9587-4425-940a-6d9afa6136ea</serial>
        </disk>
        <interface type="bridge">
            <model type="virtio"/>
            <link state="up"/>
            <source bridge="ovirtmgmt"/>
            <alias name="ua-89225df7-c084-46bc-bddd-124fcf20b452"/>
            <boot order="3"/>
            <mac address="56:6f:ce:93:00:00"/>
            <mtu size="1500"/>
            <filterref filter="vdsm-no-mac-spoofing"/>
            <bandwidth/>
        </interface>
    </devices>
    <pm>
        <suspend-to-disk enabled="no"/>
        <suspend-to-mem enabled="no"/>
    </pm>
    <os>
        <type arch="x86_64" machine="pc-i440fx-rhel7.6.0">hvm</type>
        <smbios mode="sysinfo"/>
    </os>
    <metadata>
        <ns0:qos/>
        <ovirt-vm:vm>
            <ovirt-vm:minGuaranteedMemoryMb type="int">512</ovirt-vm:minGuaranteedMemoryMb>
            <ovirt-vm:clusterVersion>4.3</ovirt-vm:clusterVersion>
            <ovirt-vm:custom/>
            <ovirt-vm:device mac_address="56:6f:ce:93:00:00">
                <ovirt-vm:custom/>
            </ovirt-vm:device>
            <ovirt-vm:device devtype="disk" name="vda">
                <ovirt-vm:poolID>043eb642-1fb0-11e9-a500-00163e3e843d</ovirt-vm:poolID>
                <ovirt-vm:volumeID>a53ec4a6-b8ce-42a1-96d3-cdad72090d13</ovirt-vm:volumeID>
                <ovirt-vm:imageID>9570d1a5-9587-4425-940a-6d9afa6136ea</ovirt-vm:imageID>
                <ovirt-vm:domainID>3f3ab345-0539-44df-9bc5-402435ed819f</ovirt-vm:domainID>
            </ovirt-vm:device>
            <ovirt-vm:launchPaused>false</ovirt-vm:launchPaused>
            <ovirt-vm:resumeBehavior>auto_resume</ovirt-vm:resumeBehavior>
        </ovirt-vm:vm>
    </metadata>
</domain> (vm:2840)