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When I boot up the system with SElinux in enforcing mode it logs:

[   25.258265] SELinux:  Completing initialization.
[   25.258266] SELinux:  Setting up existing superblocks.
[   25.286457] audit: type=1403 audit(1569965396.755:3): auid=4294967295 ses=4294967295 lsm=selinux res=1
[   25.291758] systemd[1]: Successfully loaded SELinux policy in 975.476ms.
[   25.594651] systemd[1]: Failed to insert module 'ip_tables': Operation not permitted


I'm running a fully updated x86_64 RHEL8 system with
kernel 4.18.0-80.11.2.el8_0
systemd 239-13.el8_0.5
selinux policy targeted-3.14.1-61.el8_0.2


Steps to Reproduce:
1. install Red Hat Enterprise Linux 8
2. register system and load all updates
3. setenforce enforcing
4. reboot

Actual results:
Systemd unable to load iptables module

Expected results:
iptables module loaded

Downgrading to 

selinux-policy-targeted-3.14.1-61.el8_0.1
selinux-policy-3.14.1-61.el8_0.1

does not resolve the problem.

This looks like a duplicate of https://bugzilla.redhat.com/show_bug.cgi?id=1743758 and https://bugzilla.redhat.com/show_bug.cgi?id=1644805 to me, although I don't have the necessary access to see both of those.

The workaround from #1743758 may be valid, but I have not yet tested.

Since the problem described in this bug report should be
resolved in a recent advisory, it has been closed with a
resolution of ERRATA.

For information on the advisory, and where to find the updated
files, follow the link below.

If the solution does not work for you, open a new bug report.

https://access.redhat.com/errata/RHBA-2020:1773