Description of problem: wine is not linked correctly against X libraries. Wine lib binaries for all X libs are "hard" linked to /usr/lib/wine/../libxxxx.so.x wined3d.dll.so uses /usr/lib/wine/../libGL.so.1 (mesa) not the vendor libGL which causes GLX errors . The only way to use the vendor libGL is to remove /usr/lib/libGL.so.1. Other applications use the vendor libGL. E.g. ldd /usr/lib/wine/wined3d.dll.so linux-gate.so.1 => (0x0099b000) libwine.so.1 => /usr/lib/wine/../libwine.so.1 (0x009e3000) libXxf86dga.so.1 => /usr/lib/wine/../libXxf86dga.so.1 (0x00da5000) libXxf86vm.so.1 => /usr/lib/wine/../libXxf86vm.so.1 (0x00d65000) libXext.so.6 => /usr/lib/wine/../libXext.so.6 (0x00146000) libX11.so.6 => /usr/lib/wine/../libX11.so.6 (0x005ab000) libGL.so.1 => /usr/lib/wine/../libGL.so.1 (0x007ae000) libGLU.so.1 => /usr/lib/wine/../libGLU.so.1 (0x00156000) libm.so.6 => /lib/libm.so.6 (0x00d16000) libc.so.6 => /lib/libc.so.6 (0x00af4000) libdl.so.2 => /lib/libdl.so.2 (0x00111000) libXau.so.6 => /usr/lib/wine/../libXau.so.6 (0x00115000) libXdmcp.so.6 => /usr/lib/wine/../libXdmcp.so.6 (0x00118000) libpthread.so.0 => /lib/libpthread.so.0 (0x00c5b000) libdrm.so.2 => /usr/lib/wine/../libdrm.so.2 (0x00829000) libstdc++.so.6 => /usr/lib/wine/../libstdc++.so.6 (0x006c1000) libgcc_s.so.1 => /lib/libgcc_s.so.1 (0x0011e000) /lib/ld-linux.so.2 (0x0099c000) While glxgears is linked correctly (exact same environment). ldd /usr/bin/glxgears linux-gate.so.1 => (0x0099b000) libglut.so.3 => /usr/lib/libglut.so.3 (0x00c52000) libGLU.so.1 => /usr/lib/libGLU.so.1 (0x06e03000) libGL.so.1 => /usr/lib/nvidia/libGL.so.1 (0x00119000) libm.so.6 => /lib/libm.so.6 (0x00af2000) libc.so.6 => /lib/libc.so.6 (0x009bd000) libX11.so.6 => /usr/lib/libX11.so.6 (0x00b39000) libXext.so.6 => /usr/lib/libXext.so.6 (0x00c40000) libXxf86vm.so.1 => /usr/lib/libXxf86vm.so.1 (0x06bca000) libstdc++.so.6 => /usr/lib/libstdc++.so.6 (0x063de000) libgcc_s.so.1 => /lib/libgcc_s.so.1 (0x063ac000) libGLcore.so.1 => /usr/lib/nvidia/libGLcore.so.1 (0x0019e000) libnvidia-tls.so.1 => /usr/lib/nvidia/tls/libnvidia-tls.so.1 (0x00111000) libdl.so.2 => /lib/libdl.so.2 (0x00b19000) /lib/ld-linux.so.2 (0x0099c000) libXau.so.6 => /usr/lib/libXau.so.6 (0x00b34000) libXdmcp.so.6 => /usr/lib/libXdmcp.so.6 (0x00c38000) Version-Release number of selected component (if applicable): wine-0.9.11-1.i386 How reproducible: Always, on FC5 x86_64 and x86.