ATM lvm2 doesn't do any calculation for selecting better values for VDO slab size and eventually influence sparse/dense index selection based on available system resource. For sizes over 16TiB the default VDO slab size doesn't even allow to create VDOPoolLV. lvm2 should scale up slab size if it's not defined by user. Heuristic similar to selection of chunksize for thin-pool needs to be introduced to pick more usable values.