Description of problem:
4.1-2.fc33 libreswan update is causing this issue. I'm able to get it working again by downgrading the package via 'dnf'. Example: # dnf downgrade libreswan
SELinux is preventing pluto from 'open' accesses on the file /var/lib/ipsec/nss/cert9.db.

*****  Plugin catchall_labels (83.8 confidence) suggests   *******************

If you want to allow pluto to have open access on the cert9.db file
Then you need to change the label on /var/lib/ipsec/nss/cert9.db
Do
# semanage fcontext -a -t FILE_TYPE '/var/lib/ipsec/nss/cert9.db'
where FILE_TYPE is one of the following: NetworkManager_tmp_t, abrt_helper_exec_t, abrt_tmp_t, abrt_upload_watch_tmp_t, abrt_var_cache_t, abrt_var_run_t, admin_crontab_tmp_t, alsa_tmp_t, amanda_tmp_t, antivirus_tmp_t, apcupsd_tmp_t, apmd_tmp_t, arpwatch_tmp_t, asterisk_tmp_t, auditadm_sudo_tmp_t, auditd_tmp_t, auth_home_t, automount_tmp_t, awstats_tmp_t, bacula_tmp_t, bin_t, bitlbee_tmp_t, blueman_tmp_t, bluetooth_helper_tmp_t, bluetooth_helper_tmpfs_t, bluetooth_tmp_t, boinc_project_tmp_t, boinc_tmp_t, boot_t, bootloader_tmp_t, bugzilla_tmp_t, cardmgr_dev_t, ccs_tmp_t, cdcc_tmp_t, cert_t, certmonger_tmp_t, chkpwd_exec_t, chrome_sandbox_tmp_t, chronyd_tmp_t, cinder_api_tmp_t, cinder_backup_tmp_t, cinder_scheduler_tmp_t, cinder_volume_tmp_t, cloud_init_tmp_t, cluster_conf_t, cluster_tmp_t, cluster_var_lib_t, cluster_var_run_t, cobbler_tmp_t, cockpit_tmp_t, cockpit_tmpfs_t, collectd_script_tmp_t, colord_tmp_t, comsat_tmp_t, condor_master_tmp_t, condor_schedd_tmp_t, condor_startd_tmp_t, conman_tmp_t, couchdb_tmp_t, cpu_online_t, crack_tmp_t, crond_tmp_t, crontab_tmp_t, ctdbd_tmp_t, cups_pdf_tmp_t, cupsd_lpd_tmp_t, cupsd_tmp_t, cvs_tmp_t, cyphesis_tmp_t, cyrus_tmp_t, dbadm_sudo_tmp_t, dbskkd_tmp_t, dbusd_etc_t, dcc_client_tmp_t, dcc_dbclean_tmp_t, dccd_tmp_t, dccifd_tmp_t, dccm_tmp_t, ddclient_tmp_t, deltacloudd_tmp_t, devicekit_tmp_t, dhcpc_tmp_t, dhcpd_tmp_t, dirsrv_tmp_t, dirsrvadmin_tmp_t, disk_munin_plugin_tmp_t, dkim_milter_tmp_t, dnsmasq_tmp_t, dnssec_trigger_tmp_t, dovecot_auth_tmp_t, dovecot_deliver_tmp_t, dovecot_tmp_t, drbd_tmp_t, etc_runtime_t, etc_t, exim_tmp_t, fail2ban_tmp_t, fail2ban_var_lib_t, faillog_t, fenced_tmp_t, file_context_t, firewalld_tmp_t, firewallgui_tmp_t, fonts_cache_t, fonts_t, fprintd_tmp_t, fsadm_tmp_t, fsdaemon_tmp_t, ftpd_tmp_t, ftpdctl_tmp_t, games_tmp_t, games_tmpfs_t, gconf_tmp_t, geoclue_tmp_t, getty_tmp_t, git_script_tmp_t, gkeyringd_tmp_t, glance_registry_tmp_t, glance_tmp_t, glusterd_tmp_t, gpg_agent_tmp_t, gpg_agent_tmpfs_t, gpg_pinentry_tmp_t, gpg_pinentry_tmpfs_t, gpm_tmp_t, gssd_tmp_t, home_cert_t, hostname_etc_t, hsqldb_tmp_t, httpd_php_tmp_t, httpd_suexec_tmp_t, httpd_tmp_t, ifconfig_exec_t, inetd_child_tmp_t, inetd_tmp_t, init_tmp_t, initrc_tmp_t, ipa_custodia_tmp_t, ipa_tmp_t, ipsec_conf_file_t, ipsec_exec_t, ipsec_initrc_exec_t, ipsec_key_file_t, ipsec_log_t, ipsec_mgmt_exec_t, ipsec_tmp_t, ipsec_var_run_t, iptables_exec_t, iptables_tmp_t, iscsi_tmp_t, jetty_tmp_t, kadmind_tmp_t, kdumpctl_tmp_t, kdumpgui_tmp_t, keepalived_tmp_t, keystone_tmp_t, kismet_tmp_t, kismet_tmpfs_t, klogd_tmp_t, kmod_tmp_t, krb5_conf_t, krb5_home_t, krb5_host_rcache_t, krb5_keytab_t, krb5kdc_tmp_t, ktalkd_tmp_t, l2tpd_tmp_t, l2tpd_var_run_t, lastlog_t, ld_so_cache_t, ld_so_t, ldconfig_tmp_t, lib_t, livecd_tmp_t, locale_t, logrotate_mail_tmp_t, logrotate_tmp_t, logwatch_mail_tmp_t, logwatch_tmp_t, lpd_tmp_t, lpr_tmp_t, lsassd_tmp_t, lsmd_plugin_tmp_t, lvm_tmp_t, machineid_t, mail_munin_plugin_tmp_t, mailman_cgi_tmp_t, mailman_mail_tmp_t, mailman_queue_tmp_t, man_cache_t, man_t, mandb_cache_t, mdadm_tmp_t, mediawiki_tmp_t, mock_tmp_t, mojomojo_tmp_t, mongod_tmp_t, mount_tmp_t, mozilla_plugin_tmp_t, mozilla_plugin_tmpfs_t, mozilla_tmp_t, mozilla_tmpfs_t, mpd_tmp_t, mplayer_tmpfs_t, mscan_tmp_t, munin_script_tmp_t, munin_tmp_t, mysqld_tmp_t, nagios_eventhandler_plugin_tmp_t, nagios_openshift_plugin_tmp_t, nagios_system_plugin_tmp_t, nagios_tmp_t, named_cache_t, named_tmp_t, net_conf_t, netutils_tmp_t, neutron_tmp_t, nfsd_tmp_t, nova_tmp_t, nsd_tmp_t, ntop_tmp_t, ntpd_tmp_t, nut_upsd_tmp_t, nut_upsdrvctl_tmp_t, nut_upsmon_tmp_t, nx_server_tmp_t, opendnssec_tmp_t, openshift_app_tmp_t, openshift_cgroup_read_tmp_t, openshift_cron_tmp_t, openshift_initrc_tmp_t, openshift_tmp_t, openvpn_tmp_t, openvswitch_tmp_t, openwsman_tmp_t, oracleasm_tmp_t, pam_timestamp_exec_t, pam_timestamp_tmp_t, passenger_tmp_t, passwd_file_t, pcp_tmp_t, pcscd_var_run_t, pegasus_openlmi_storage_tmp_t, pegasus_tmp_t, pesign_tmp_t, piranha_web_tmp_t, pkcs11_modules_conf_t, pkcs_slotd_tmp_t, pki_tomcat_tmp_t, podsleuth_tmp_t, podsleuth_tmpfs_t, policykit_tmp_t, portmap_tmp_t, postfix_bounce_tmp_t, postfix_cleanup_tmp_t, postfix_local_tmp_t, postfix_map_tmp_t, postfix_pickup_tmp_t, postfix_pipe_tmp_t, postfix_qmgr_tmp_t, postfix_smtp_tmp_t, postfix_smtpd_tmp_t, postfix_virtual_tmp_t, postgresql_tmp_t, pppd_tmp_t, prelink_exec_t, prelink_tmp_t, prelude_lml_tmp_t, proc_t, procmail_tmp_t, prosody_tmp_t, psad_tmp_t, pulseaudio_tmpfs_t, puppet_tmp_t, puppetmaster_tmp_t, qpidd_tmp_t, rabbitmq_tmp_t, racoon_tmp_t, realmd_tmp_t, redis_tmp_t, rhev_agentd_tmp_t, rhsmcertd_tmp_t, ricci_tmp_t, rkhunter_var_lib_t, rlogind_tmp_t, rolekit_tmp_t, rpcbind_tmp_t, rpm_script_tmp_t, rpm_tmp_t, rpmdb_tmp_t, rrdcached_tmp_t, rsync_tmp_t, rtas_errd_tmp_t, samba_etc_t, samba_net_tmp_t, samba_var_t, sbd_tmpfs_t, sblim_tmp_t, secadm_sudo_tmp_t, sectool_tmp_t, security_t, selinux_munin_plugin_tmp_t, semanage_tmp_t, sendmail_tmp_t, services_munin_plugin_tmp_t, session_dbusd_tmp_t, setroubleshoot_fixit_tmp_t, setroubleshoot_tmp_t, sge_tmp_t, shell_exec_t, shorewall_tmp_t, slapd_tmp_t, smbd_tmp_t, smoltclient_tmp_t, smsd_tmp_t, snort_tmp_t, sosreport_tmp_t, soundd_tmp_t, spamc_tmp_t, spamd_tmp_t, speech_dispatcher_tmp_t, squid_tmp_t, squirrelmail_spool_t, src_t, ssh_agent_tmp_t, ssh_keygen_tmp_t, ssh_tmpfs_t, sssd_public_t, sssd_var_lib_t, staff_sudo_tmp_t, stapserver_tmp_t, stapserver_tmpfs_t, stunnel_tmp_t, svirt_tmp_t, svnserve_tmp_t, swat_tmp_t, swift_tmp_t, sysadm_passwd_tmp_t, sysadm_sudo_tmp_t, sysctl_fs_t, sysfs_t, syslogd_tmp_t, system_conf_t, system_cronjob_tmp_t, system_db_t, system_dbusd_tmp_t, system_dbusd_var_lib_t, system_mail_tmp_t, system_munin_plugin_tmp_t, systemd_importd_tmp_t, systemd_logind_sessions_t, targetd_tmp_t, tcpd_tmp_t, telepathy_gabble_tmp_t, telepathy_idle_tmp_t, telepathy_logger_tmp_t, telepathy_mission_control_tmp_t, telepathy_msn_tmp_t, telepathy_salut_tmp_t, telepathy_sofiasip_tmp_t, telepathy_stream_engine_tmp_t, telepathy_sunshine_tmp_t, telnetd_tmp_t, tetex_data_t, textrel_shlib_t, tgtd_tmp_t, thumb_tmp_t, tmp_t, tomcat_tmp_t, tuned_tmp_t, tvtime_tmp_t, tvtime_tmpfs_t, udev_tmp_t, udev_var_run_t, uml_tmp_t, uml_tmpfs_t, unconfined_munin_plugin_tmp_t, updpwd_exec_t, user_fonts_t, user_mail_tmp_t, user_tmp_t, usr_t, uucpd_tmp_t, var_spool_t, varnishd_tmp_t, virt_qemu_ga_tmp_t, virt_tmp_t, virt_var_lib_t, vmtools_tmp_t, vmware_host_tmp_t, vmware_tmp_t, vmware_tmpfs_t, vpnc_tmp_t, w3c_validator_tmp_t, webadm_tmp_t, webalizer_tmp_t, wireshark_tmp_t, wireshark_tmpfs_t, wtmp_t, xauth_tmp_t, xend_tmp_t, xenstored_tmp_t, xserver_tmpfs_t, ypbind_tmp_t, ypserv_tmp_t, zabbix_tmp_t, zarafa_deliver_tmp_t, zarafa_indexer_tmp_t, zarafa_server_tmp_t, zarafa_var_lib_t, zebra_tmp_t.
Then execute:
restorecon -v '/var/lib/ipsec/nss/cert9.db'


*****  Plugin catchall (17.1 confidence) suggests   **************************

If you believe that pluto should be allowed open access on the cert9.db file by default.
Then you should report this as a bug.
You can generate a local policy module to allow this access.
Do
allow this access for now by executing:
# ausearch -c 'pluto' --raw | audit2allow -M my-pluto
# semodule -X 300 -i my-pluto.pp

Additional Information:
Source Context                system_u:system_r:ipsec_t:s0
Target Context                system_u:object_r:var_lib_t:s0
Target Objects                /var/lib/ipsec/nss/cert9.db [ file ]
Source                        pluto
Source Path                   pluto
Port                          <Unknown>
Host                          (removed)
Source RPM Packages           
Target RPM Packages           
SELinux Policy RPM            selinux-policy-targeted-3.14.6-30.fc33.noarch
Local Policy RPM              selinux-policy-targeted-3.14.6-30.fc33.noarch
Selinux Enabled               True
Policy Type                   targeted
Enforcing Mode                Enforcing
Host Name                     (removed)
Platform                      Linux (removed) 5.9.11-200.fc33.x86_64 #1 SMP Tue
                              Nov 24 18:18:01 UTC 2020 x86_64 x86_64
Alert Count                   2
First Seen                    2020-12-01 08:43:01 EST
Last Seen                     2020-12-01 08:43:01 EST
Local ID                      e7f7e893-7b4c-475f-bf95-09185de4bd8a

Raw Audit Messages
type=AVC msg=audit(1606830181.508:1174): avc:  denied  { open } for  pid=7508 comm="pluto" path="/var/lib/ipsec/nss/cert9.db" dev="dm-0" ino=2753975 scontext=system_u:system_r:ipsec_t:s0 tcontext=system_u:object_r:var_lib_t:s0 tclass=file permissive=0


Hash: pluto,ipsec_t,var_lib_t,file,open

Version-Release number of selected component:
selinux-policy-targeted-3.14.6-30.fc33.noarch

Additional info:
component:      selinux-policy
reporter:       libreport-2.14.0
hashmarkername: setroubleshoot
kernel:         5.9.11-200.fc33.x86_64
type:           libreport