Description of problem:
This happened out of the blue while updating the policy. Unsure whether this is an artifact of the smartmontools-selinux upgrade with a running smartd (that could be worked around with other installation scripts maybe) or something lasting. Will continue observing.
SELinux is preventing smartd from 'read' accesses on the chr_file nvme0.

*****  Plugin catchall (100. confidence) suggests   **************************

Wenn Sie denken, dass es smartd standardmäßig erlaubt sein sollte, read Zugriff auf nvme0 chr_file zu erhalten.
Then sie sollten dies als Fehler melden.
Um diesen Zugriff zu erlauben, können Sie ein lokales Richtlinien-Modul erstellen.
Do
zugriff jetzt erlauben, indem Sie die nachfolgenden Befehle ausführen:
# ausearch -c 'smartd' --raw | audit2allow -M my-smartd
# semodule -X 300 -i my-smartd.pp

Additional Information:
Source Context                system_u:system_r:fsdaemon_t:s0
Target Context                system_u:object_r:nvme_device_t:s0
Target Objects                nvme0 [ chr_file ]
Source                        smartd
Source Path                   smartd
Port                          <Unbekannt>
Host                          (removed)
Source RPM Packages           
Target RPM Packages           
SELinux Policy RPM            selinux-policy-targeted-3.14.6-39.fc33.noarch
Local Policy RPM              smartmontools-selinux-7.2-7.fc33.noarch
Selinux Enabled               True
Policy Type                   targeted
Enforcing Mode                Enforcing
Host Name                     (removed)
Platform                      Linux (removed) 5.13.8-100.fc33.x86_64 #1 SMP Wed
                              Aug 4 14:15:51 UTC 2021 x86_64 x86_64
Alert Count                   1
First Seen                    2021-08-14 11:50:47 CEST
Last Seen                     2021-08-14 11:50:47 CEST
Local ID                      efde4a5f-7f46-4c37-9370-08877cf4f83a

Raw Audit Messages
type=AVC msg=audit(1628934647.769:169405): avc:  denied  { read } for  pid=552729 comm="smartd" name="nvme0" dev="devtmpfs" ino=314 scontext=system_u:system_r:fsdaemon_t:s0 tcontext=system_u:object_r:nvme_device_t:s0 tclass=chr_file permissive=0


Hash: smartd,fsdaemon_t,nvme_device_t,chr_file,read

Version-Release number of selected component:
selinux-policy-targeted-3.14.6-39.fc33.noarch

Additional info:
component:      smartmontools
reporter:       libreport-2.15.2
hashmarkername: setroubleshoot
kernel:         5.13.8-100.fc33.x86_64
type:           libreport