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Maybe dupe of bug 2015825? Could you try the workaround mentioned in the bug 2015825?

(In reply to Jaroslav Škarvada from comment #2)
> Maybe dupe of bug 2015825? Could you try the workaround mentioned in the bug
> 2015825?

Confirmed the workaround (`yum reinstall -y grub2-common` before reboot) works.  Realtime tuned profile now applied:

[root@supermicro-X12DHM-6-02 ~]# cat /proc/cmdline 
BOOT_IMAGE=(hd1,gpt2)/vmlinuz-5.14.0-146.rt21.146.el9.x86_64 root=/dev/mapper/rhel_supermicro--x12dhm--6--02-root ro efi=runtime crashkernel=1G-4G:192M,4G-64G:256M,64G-:512M resume=/dev/mapper/rhel_supermicro--x12dhm--6--02-swap rd.lvm.lv=rhel_supermicro-x12dhm-6-02/root rd.lvm.lv=rhel_supermicro-x12dhm-6-02/swap console=ttyS1,115200N81 skew_tick=1 isolcpus=managed_irq,domain,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108,109,110,111 intel_pstate=disable nosoftlockup tsc=reliable

Marking this as a DUPE.  Thanks Jaroslav

*** This bug has been marked as a duplicate of bug 2015825 ***