As seen in https://artifacts.dev.testing-farm.io/03533289-6f2e-43cc-a169-5d4a793d8ae0/ annocheck reports fortify as failed in i686 binaries with one of these two messages:

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Hardened: /usr/bin/valgrind: FAIL: fortify test because no indication that the necessary option was used (and a C compiler was detected) (source: final scan)
----- or -----
Hardened: /usr/bin/valgrind-listener: FAIL: fortify test because -D_FORTIFY_SOURCE=[2|3] was not present on the command line (function: setsockopt) (source: annobin notes)
--------------

The binaries are coming from valgrind-3.21.0-5.fc39 (https://koji.fedoraproject.org/koji/buildinfo?buildID=2207502). However this test passes for the binaries inside valgrind-3.21.0-4.fc39 (https://koji.fedoraproject.org/koji/buildinfo?buildID=2202010), and these were compiled and linked with the exact same flags.

I also ran annocheck directly on the files of both valgrind builds to check that this is not caused by rpminspect: 

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[/var/tmp/rpminspect/local.lbRZ70/root]
$ annocheck --ignore-unknown --skip-lto --profile=rawhide after/i686/usr/bin/valgrind --debug-file=after/i686/usr/lib/debug/usr/bin/valgrind-3.21.0-5.fc39.i386.debug 
annocheck: Version 12.10.
Hardened: using profile: rawhide.
Hardened: valgrind: FAIL: fortify test because no indication that the necessary option was used (and a C compiler was detected) 
Hardened: Rerun annocheck with --verbose to see more information on the tests.
Hardened: valgrind: Overall: FAIL.
[/var/tmp/rpminspect/local.lbRZ70/root]
$ annocheck --ignore-unknown --skip-lto --profile=rawhide before/i686/usr/bin/valgrind --debug-file=before/i686/usr/lib/debug/usr/bin/valgrind-3.21.0-4.fc39.i386.debug 
annocheck: Version 12.10.
Hardened: using profile: rawhide.
Hardened: valgrind: PASS.
--------------

Reproducible: Always

Steps to Reproduce:
1. rpminspect-fedora -v -a i686 -T annocheck valgrind-3.21.0-5.fc39

Actual Results:  
fortify test failed in /usr/bin/valgrind, /usr/bin/valgrind-listener, /usr/bin/vgdb

Expected Results:  
fortify test pass.