This file in nanopb, included "in case you want to run it with Python 2", has a python2 shebang that makes RPM automatically generate a requirement on /usr/bin/python2:

   /usr/lib/python3.12/site-packages/nanopb/generator/nanopb_generator.py2


Please either
- remove the file (and anything that needs it, like protoc-gen-nanopb-py2s) or
- filter out the automatic dependency like this:

  %global __requires_exclude ^/usr/bin/python2$

(see https://docs.fedoraproject.org/en-US/packaging-guidelines/AutoProvidesAndRequiresFiltering/#_filtering_provides_and_requires_after_scanning . I haven't tested the suggestion.)

Thanks!