I tried to see how pulseaudio handles suspend/resume, and I was somewhat disappointed. After resume, I don't get any sound anymore, and a rhythmbox that was playing music before the resume just blocks in FUTEX_WAIT without even redrawing its ui. I haven't tested it yet, but there is a pulseaudio patch in http://pulseaudio.org/ticket/26 which may be relevant to this.
The Ubuntu packages carry that patch, fwiw.
New patch in package.