When running Blender on Fedora Workstation 43(GNOME, Wayland), the Preferences window does not open and all menus starting from the File menu are grayed out.

 I test flatpak(flathub), occur the issue too. So the issue may be not rpm-specific. On Fluxbox(host) and Fedora KDE Edition(gnome-boxes), the menus work correctly.

This suggests the problem is related to the GNOME Wayland session rather than Blender itself.

Version-Release number of selected component:

blender-4.5.3-1.fc43.x86_64
xdg-desktop-portal-gnome-49.0-1.fc43.x86_64
xdg-desktop-portal-gtk-1.15.3-2.fc43.x86_64
xdg-desktop-portal-1.20.3-2.fc43.x86_64

Some Environments are in Additional Information

Reproducible: Always

Steps to Reproduce:
1.Install Blender from Fedora RPM packages or Install blender from flatpak install com.blender.Blender
2.Run Blender 
3.Try to open Preferences or any menu starting from the File menu.
Actual Results:
The Preferences window does not open.
All menus starting from the File menu are grayed out.

Expected Results:
The Preferences window should open normally.
Menus should be accessible as expected.

Additional Information:
Test Environments 

Host: NVIDIA driver
- Fedora Workstation 43
- Fedora Workstation 42
- Fluxbox window manager

gnome-boxes guests (virtio display):
- Fedora Workstation 43
- Fedora Workstation 42
- Fedora KDE Edition 43

Environments where menus are grayed out:

- Host: Fedora Workstation 43
- Flatpak(flathub) on Host

- gnome-boxes guest: Fedora Workstation 43

Environments where menus are not grayed out:

- Host: Fluxbox
- Host and gnome-boxes: Fedora Workstation 42
- gnome-boxes guest: Fedora KDE Edition 43

xdg-desktop-portal warnings (shown in all environments):

/usr/libexec/xdg-desktop-portal[1861]: Realtime error : Could not get pidns for pid XXXX: Could not fstatat ns/pid: Not a directory

EGL errors:

- Fedora Workstation 42 and 43 (host, NVIDIA driver): no error.
- gnome-boxes guests (all), and host with nouveau driver (Workstation 43):

libEGL warning: egl: failed to create dri2 screen EGL Error (0x3009): EGL_BAD_MATCH: Arguments are inconsistent
  
 Despite EGL errors, KDE Edition and Fedora 42 guests do not show the grayed-out behavior.

- Fedora 43 Workstation host: no EGL error, but menus are grayed out.
- Fedora 43 Workstation gnome-boxes guest: EGL error occurs and menus are grayed out.