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python-cryptography is a package designed to expose cryptographic primitives and recipes to Python developers. Prior to 49.0.0, when resolving invalid certificate chains that include duplicate copies of self-signed certificates, the processing recursively invokes the same candidate, leading to an exponential blowup. Although the limitation that the chain depth cannot exceed a specified maximum depth prevents unbounded recursion and guarantees termination, an attacker-controlled certificate chain can lead the processing to easily take more than 5s to reject in testing. This amplification could form the basis for a resource exhaustion denial of service attack. The core issue arises in the recursive nature of build_chain_inner, which does not de-duplicate against previously analyzed candidates. As the correctness of validation is not affected, the integrity of a system cannot be compromised through this vector, only its availability. This issue is fixed in 49.0.0.