HDF5 through 2.2.0 contains a NULL pointer dereference vulnerability in H5HL_unprotect() in src/H5HL.c. H5HL_protect() pins a single metadata cache entry for a local heap, either the heap prefix or the separate data block, and H5HL_unprotect() unpins it on the final unprotect. When the metadata cache destroys a corrupted local heap entry, H5HL__prfx_dest() unlinks it from the heap by setting heap->prfx or heap->dblk to NULL. A crafted HDF5 file can therefore reach H5HL_unprotect() with no cached object to unpin, and the function passes the NULL pointer to H5AC_unpin_entry(). This causes an assertion failure in debug builds and a NULL pointer dereference and crash in release builds. An attacker who can get a user or application to open and traverse a malicious file can cause a denial of service.