As of gnome-python2-2.22.1-3.fc10, the Python bindings for libgnome and libgnomeui have moved to a new subpackage named gnome-python2-gnome. Consequently, this package _may_ need to change its gnome-python2 requirement to gnome-python2-gnome. The reason for this change is because libgnome and libgnomeui pull in a large number of dependencies that some of the gnome-python2 subpackages -- such as gnome-python2-gnomevfs -- don't need, but subpackages must still require their parent package. Splitting the libgnome[ui] bindings into a subpackage allows the other subpackages to avoid pulling in lots of unnecessary libgnome[ui] dependencies. See bug #456122 for more details.
Thanks for the heads up. I'll look into this later tonight.
After reviewing the source it looks like meld needs the libgnomeui binding, so I've changed the requires in meld according to the change in bug #456122. Fixed in meld-1.2-2.fc10