When a large number of LUNs are added to a node, multipath can significantly increase the time it takes for udev to create device nodes for them. If you experience this problem, you can correct it by deleting the following line in /etc/udev/rules.d/40-multipath.rules:
KERNEL!="dm-[0-9]*", ACTION=="add", PROGRAM=="/bin/bash -c '/sbin/lsmod | /bin/grep ^dm_multipath'", RUN+="/sbin/multipath -v0 %M:%m"
This line causes udev to run multipath every time a block device is added to the node. Even with this line remove, multipathd will still automatically create multipath devices, and multipath will still be called during the boot process, for nodes with multipathed root filesystems. The only change is that multipath devices will not be automatically created when multipathd is not running, which should not be a problem for the vast majority of multipath users.