Currently, if you right-click .iso files in nautilus, you get the options to open them with archive mounter, archive manager or brasero, so you can browse or burn the image.
It would be very nice if Virt-Manager was listed. If selected, a dialog similar to the current "new vm" dialog would pop up. Basicly, all the options of 'new vm' should be there, plus the option to not actually save this VM configuration for the cases where you just want to boot the live cd once.
The nautilus integration itself would be as simple as providing a .desktop file like this:
Name=Virtual Machine Manager
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Still relevant, moving to F15
Moving to upstream tracker
Boxes handles this sort of tight desktop integration nowadays, so closing as WONTFIX