This bug has been copied from bug #651512 and has been proposed to be backported to 5.6 z-stream (EUS).
in kernel-2.6.18-238.3.1.el5 linux-2.6-net-e1000-avoid-unhandled-irq.patch linux-2.6-net-e1000-fix-screaming-irq.patch
An advisory has been issued which should help the problem described in this bug report. This report is therefore being closed with a resolution of ERRATA. For more information on therefore solution and/or where to find the updated files, please follow the link below. You may reopen this bug report if the solution does not work for you. http://rhn.redhat.com/errata/RHSA-2011-0303.html
Technical note added. If any revisions are required, please edit the "Technical Notes" field accordingly. All revisions will be proofread by the Engineering Content Services team. New Contents: While bringing down an interface, the e1000 driver failed to properly handle IRQs (Interrupt Requests), resulting in the reception of the following messages: irq NN: nobody cared... With this update, the driver's down flag is set later in the process of bringing down an interface, specifically, after all timers have exited, preventing the IRQ handler from being called and exiting early without handling the IRQ.