If you use an extension module that links with libpthread, problems related to errno occur (this is because some of the code will use the normal single threaded errno variable, and code loaded after pthread uses (*__errno_location()). These problems can be fixed by LD_PRELOADing libpthread or by building thread support into python. The second option is easier for users, and also allows threaded python programs to run out of the box on redhat systems. I have only just started to see these problems while developing pygtk and gnome-python packages (since GTK recently became threaded). If you intend to include gnome-python with the GNOME distribution, this change will be needed to make gnome-python usable.
fixed in a later python release