Hi,
Sorry for noncomplete description :-)

When tuned not running
changing profiles (tuned-adm) causes error
Cannot read /var/run/tuned/tuned.pid: [Errno 2] No such file or directory: '/var/run/tuned/tuned.pid'

I think that command tuned-adm, should shouw better message (for example start tuned, before using tuned-adm)
or start tuned automatically when try to change profile, or other useful thing.
   Regards
   Honza

Do you run it as root?

Yes I do. I was root

For jscotka: probably the same problem, in the test case prereq there is systemctl start tuned.service, so it needs to be run.

For refence 'cat pmtd-selinux-test':
echo -n "AVCs: "
ausearch -m avc -m user_avc -i
setenforce 1
for I in `tuned-adm list | grep "^- " | cut -d ' ' -f 2` ; do
  echo -n > /var/log/audit/audit.log
  tuned-adm active
  echo "* Switching to profile: $I"
  tuned-adm profile $I
  sleep 5
  echo -n "AVCs: "
  ausearch -m avc -m user_avc -i
done

Resolved upstream, we are switching tuned-adm to DBus. The update is comming soon.

*** Bug 858075 has been marked as a duplicate of this bug. ***

tuned-2.1.0-1.fc18 has been submitted as an update for Fedora 18.
https://admin.fedoraproject.org/updates/tuned-2.1.0-1.fc18

Resolved in:
tuned-2.1.0-1.fc18
tuned-2.1.0-1.fc19

Package tuned-2.1.0-1.fc18:
* should fix your issue,
* was pushed to the Fedora 18 testing repository,
* should be available at your local mirror within two days.
Update it with:
# su -c 'yum update --enablerepo=updates-testing tuned-2.1.0-1.fc18'
as soon as you are able to.
Please go to the following url:
https://admin.fedoraproject.org/updates/FEDORA-2012-19556/tuned-2.1.0-1.fc18
then log in and leave karma (feedback).

tuned-2.1.1-1.fc18 has been submitted as an update for Fedora 18.
https://admin.fedoraproject.org/updates/tuned-2.1.1-1.fc18

tuned-2.1.1-1.fc18 has been pushed to the Fedora 18 stable repository.  If problems still persist, please make note of it in this bug report.